Alzheimer’s disease (AD) model mice are stimulated with non-invasive 40-Hz multisensory flicker (Gamma ENtrainment Using Sensory stimulus, or GENUS), which has been shown to reduce extracellular aggregates of amyloid beta peptides, a hallmark of AD pathology, and elicit a glial response in the somatosensory cortex. Here, microglia (blue), the resident immune cells of the brain, are observed to be “attacking” the amyloid plaques (red) in the auditory cortex after GENUS is administered.